Haissi Cui

We will use chemical tools to understand and manipulate how RNA maturation and decoding are spatially regulated in the etiology of human disease. In all living beings, information is stored as DNA, transcribed into RNA, and translated into proteins and disruption of this process at any step has severe consequences. The group will combine small molecule compounds, protein and genome engineering, and cell biology to understand how the localization of RNA and protein in the cell can impact inflammation, neurological diseases, and developmental disorders. The long-term goal of the lab is to translate new discoveries in this space into potential avenues for therapeutics but also to follow our curiosity and study new and unexpected functions of biomolecules.