Course Information

An introduction to the key concepts in the design, manufacture, and use of efficacious dosage forms.  The course covers the characteristics of different delivery routes.

Prerequisite: (CHM135H1, CHM136H1)/(CHM138H1, CHM139H1)/CHM151Y1; CHM220H1/CHM222H1

Exclusion:  PHC330Y1; PHM141H1

Structural and mechanistic determinants of drug action at the molecular level. Topics include the physical-chemical properties of drugs per se as they relate to therapeutic intervention and the biophysical and biochemical properties of enzymes and nucleic acids that underlie and are affected by their interactions with drugs.

Prerequisite: (CHM135H1, CHM136H1)/(CHM138H1, CHM139H1)/CHM151Y1; CHM220H1/CHM222H1

Exclusion:  PCL302H1; PHC300Y1

Structural and mechanistic determinants of drug action via macromolecules that effect cellular signalling. Neurohumoral receptors and other signalling proteins are grouped according to their structure and mechanism of action. Native properties and their modulation by drugs are discussed in the context of basic principles of molecular pharmacology.

Prerequisite:  BCH210H1; (CHM135H1, CHM136H1)/(CHM138H1, CHM139H1)/CHM151Y1; CHM220H1/CHM222H1

Exclusion:  PCL302H1; PHC300Y1; PHM140H1

Modern discovery and synthesis of antibiotics, antineoplastics, antiviral and other therapeutic agents.

Prerequisite: BCH210H1; CHM247H1/249H1

This course presents a detailed examination of the material properties of pharmaceuticals and the role of cellular processes in delivery of a drug to its site of action.

Prerequisite: (CHM135H1, CHM136H1)/(CHM138H1, CHM139H1)/CHM151Y1; CHM220H1/CHM222H1

Exclusion:  PHC330Y1

Introduction to human clinical trial design for the demonstration of pharmaceutical bioequivalence of drug products. Students will learn the principles underlying the regulations and methods employed in bioequivalence studies.

Prerequisites: BCH210H1; CHM247H1/249H1; (MAT135H1, MAT136H1)/MAT135Y1

Pre- or co-requisite: (PHC230H1, PHC330H1)

The scientific basis and practical techniques relevant to modern pharmaceutical development.

Prerequisite: BCH210H1; (CHM220H1, CHM221H1)/CHM223H1; CHM247H1/249H1

The goal of this course is to provide students with knowledge of the molecular processes involved in drug transport across biological cell membranes with emphasis on their physiological and clinical significance.

Prerequisite: PHC300H1, PHC301H1, and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.

This course shows students the links between basic science and the drugs used therapeutically to treat clinical problems.

Prerequisite: PHC301H1, PHC320H1

This course provides students with a fundamental knowledge of the thermodynamics of the non-covalent interactions important in biochemical interactions and drug development.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.

Introduction to controlled drug delivery: Mechanisms and kinetics of controlled drug release.

Fundamental theories and mathematical tools for the design of modern dosage forms. Development and applications of controlled drug delivery dosage forms.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemisty specialist program.

In-depth discussion of implementation of pharmaceutical sciences in drug development strategies.

Students will apply fundamental principles of pharmaceutics and drug delivery to current problems in the pharmaceutical industry.

Prerequisite:  Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.

Recommended: (PHC230H1, PHC330H1)/PHC330Y1; PHC340Y1

This course covers topics that pertain to the development and application of nanomedicines in oncology. Students will gain an understanding of the biological barriers to drug delivery in oncology as well as the heterogeneity in cancer and the challenge this presents for treatment. Passive and active targeting of nanomedicines will be covered with critical assessment of the enhanced permeability and retention effect. Emphasis on evaluation of scientific literature and pre-clinical/clinical studies will be made throughout the course.

Prerequisite: PHC230H1, PHC330H1 and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.

Application and development of devices for the purpose of collecting and analyzing experimental data in pharmaceutical development and manufacture.

Prerequisite: BCH210H1, CHM247H1/CHM249H1, (MAT135H1, MAT136H1)/MAT137Y1, PHC340Y1 and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.

Lectures by scientists from academia and industry, and student seminars based on journal articles dealing with strategies for discovering new drugs for therapy and diagnosis.

Prerequisites: BIO120H1, BIO130H1; PHC301H1/PHC300Y1/PHM222Y1, and enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.

This course is designed to broaden students’ understanding of the development and licensing of new drugs and how scientific principles, ethics, governmental regulations, and commercial considerations are coordinated for designing clinical trials. The format involves lectures, group discussion and student presentations.

Prerequisite: PHC230H1, PHC301H1, PHC340Y1

Introduces concepts and issues in international pharmaceutical policy. Emphasis placed on how govern­ments in different jurisdictions manage their public health responsibilities, international obligations, and pressure from special interest groups in terms of pharmaceutical policy.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.

This course will provide research experience under the supervision of a faculty member in the Graduate Department of Pharmaceutical Sciences. The goal is to deepen the student’s understanding of the scientific basis and practical techniques relevant to modern pharmaceutical development.

Prerequisite: Enrolled as a Year 4 student in the Pharmaceutical Chemistry specialist program.